File Name: oxidative stress exercise and antioxidant supplementation .zip
Context: Overproduction of reactive oxygen and nitrogen species during physical exercise, exercise induced oxidative stress and antioxidant supplementation is interesting and controversial concepts that have been considered during the past decades. Evidence Acquisition: In this review, we aimed to summarize current evidence in relation to antioxidant supplementation outcomes during exercise and physical activity. For this aim, we obtained relevant articles through searches of the Medline and PubMed databases between to Although major studies have indicated that antioxidants could attenuate biomarkers of exercise-induced oxidative stress and the use of antioxidant supplement is a common phenomenon among athletes and physically active people, there are some doubts regarding the benefits of these.
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Antioxidant supplementation to the exercising horse. Evidence of oxidative stress in horses has been described in reports dealing with intense and endurance exercise. Oxidative stress occurs when antioxidant systems are insufficient causing oxidation to potentially damage DNA, proteins, and lipids, and contribute to degenerative changes. Vitamin E is the most commonly supplemented antioxidant in horses and has been shown that horses in exercise conditioning may require higher intakes of vitamin E than recommended. Also in various species vitamin C potentiates the effects of vitamin E; however, under maintenance conditions horses have the ability to synthesize sufficient ascorbate, the demand increases as stress on the body is increased. Competitive endurance horses were estimated to consume 1. In these horses a negative correlation was found between the vitamin E intake and creatine kinase, and aspartate aminotransferase.
DOI : Objective: Numerous epidemiological studies show an increased prevalence of metabolic diseases related to oxidation stress causing cell damage. Antioxidant supplementation is therefore useful to protect against the oxidative stress mediated disease development and has become an increasingly popular practice. In this review, a selection of clinical and in vitro studies on vitamin C and E supplementation and the evaluation of their beneficial or negative effects have been analyzed. Keywords: Diseases, health, negative effect, supplementation, vitamin C, vitamin E. Abstract: Objective: Numerous epidemiological studies show an increased prevalence of metabolic diseases related to oxidation stress causing cell damage.
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Ljiljana M. Popovic, Nebojsa R. Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase MPO in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules.
Antioxidant uptake and regular exercise are two well-acknowledged measures used for rejuvenation and oxidative stress elimination. Previous studies have revealed that moderate exercise mildly increases intracellular signaling oxidant levels and strengthens the ability of an organism to deal with escalating oxidative stress by upregulating antioxidant enzymes, such as superoxide dismutase SOD , catalase CAT , and glutathione peroxidase. Antioxidant supplementation directly scavenges intracellular reactive oxygen species ROS to reduce oxidative stress. However, research to understand the impacts of these enzymes on mitigating oxidative stress from the perspective of simple animals is limited.
The health-promoting effects of antioxidant vitamins C and E supplementation are unclear. This study investigated the effects of vitamins C and E on the activities of reactive oxygen species ROS -scavenging enzymes and protein and lipid peroxidation statuses under resting and exercise-induced conditions. Thirteen healthy, previously untrained males age 20—21 years participated in this study.
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